UCX® have the potential to promote a full range of events leading to tissue regeneration and homeostasis as demonstrated in induced hindlimb ischemia (HLI) in animal models. UCX® was shown to enhance angiogenesis in vitro via a paracrine effect. Importantly, after HLI induction, UCX® improved blood perfusion by stimulating angiogenesis and arteriogenesis. This was achieved through a new mechanism in which durable and simultaneous upregulation of transforming growth factor β2, angiopoietin 2, fibroblast growth factor 2, and hepatocyte growth factor were induced in surrounding endothelial cells.The data demonstrates that UCX® improves the angiogenic potency of endothelial cells in the murine ischemic limb suggesting its potential as a new therapeutic tool for critical limb ischemia. Read more in Pereira et al. (2016), Stem Cell Research & Therapy, DOI: 10.1186/s13287-016-0410-4.